abstract：:The protein binding of four non-depolarizing neuromuscular blocking drugs-tubocurarine, fazadinium, pancuronium and Org NC45-was measured, in serum from normal patients and from patients with cirrhosis of the liver, by an ultracentrifugation method. The fraction bound to serum protein in normal patients was 56% for tu...

journal_title：British journal of anaesthesia

authors： Duvaldestin P,Henzel D

更新日期：1982-05-01 00:00:00

abstract：:The effects of different premedication (i.m. and i.v.) on the usefulness of midazolam or thiopentone as induction agents for minor surgery was studied in 194 women undergoing either dilatation and curettage or explorative fractionate curettage. Midazolam appeared to produce light sedation which required powerful preme...

journal_title：British journal of anaesthesia

authors： Kanto J,Sjövall S,Vuori A

更新日期：1982-05-01 00:00:00

abstract：:The effects of Org NC 45 and pancuronium bromide on heart rate and arterial pressure were studied in anaesthetized man. A bolus of either Org NC 45 0.1 mg kg-1 or pancuronium 0.1 mg kg-1 was administered to lightly anaesthetized unstimulated subjects. Following Org NC 45 heart rate decreased in the majority of subject...

journal_title：British journal of anaesthesia

authors： Barnes PK,Smith GB,White WD,Tennant R

更新日期：1982-04-01 00:00:00

abstract：:The effects of physostigmine 1 mg i.v. were studied on the analgesia, sedation and reduction in respiratory rate induced by morphine 10 mg/60 kg i.v. in 10 patients recovering from surgery. Within 5-10 min, physostigmine abolished the somnolent effect of morphine and restored the respiratory rate to pre-drug values. A...

journal_title：British journal of anaesthesia

authors： Weinstock M,Davidson JT,Rosin AJ,Schnieden H

更新日期：1982-04-01 00:00:00

abstract：:A 4-year-old girl developed severe hepatitis following the fourth administration of halothane in a period of 5 months. She was shown to have a circulating antibody which acted specifically against rabbit hepatocyte previously sensitized to halothane. The patient made a full recovery from the hepatitis, but 5 months la...

journal_title：British journal of anaesthesia

authors： Lewis RB,Blair M

更新日期：1982-03-01 00:00:00

abstract：:The effect of ketamine analgesia on gastric emptying was assessed in five healthy volunteers. Gastric emptying, estimated indirectly by the absorption of orally administered paracetamol, was not significantly delayed following administration of i.m. ketamine when compared with placebo. ...

journal_title：British journal of anaesthesia

authors： Grant IS,Nimmo WS,Clements JA

更新日期：1981-12-01 00:00:00

abstract：:The pharmacokinetics of edrophonium were determined in patients anaesthetized with nitrous oxide and halothane undergoing kidney transplant nephrectomy (n=6) or transplantation of a live related donor kidney (n = 6). Serum concentrations of edrophonium were assayed by high pressure liquid chromatography and pharmacoki...

journal_title：British journal of anaesthesia

authors： Morris RB,Cronnelly R,Miller RD,Stanski DR,Fahey MR

更新日期：1981-12-01 00:00:00

abstract：:The use of di-isopropyl phenol (Diprivan) for induction of anaesthesia was assessed in doses ranging from 1 to 3 mg kg-1. With less than 1.75mg kg-1 not all patients were anaesthetized; 2.0 mg kg-1 appeared to be a satisfactory induction dose. Involuntary muscle movement, cough and hiccup at induction were rare with a...

journal_title：British journal of anaesthesia

authors： Briggs LP,Clarke RS,Dundee JW,Moore J,Bahar M,Wright PJ

更新日期：1981-11-01 00:00:00

abstract：:One hundred and forty male rats received a cryoinjury to a segment of the exposed sciatic nerve. A variety of temperatures and freeze patterns was used and the recovery of function was monitored. Where obvious nerve freezing occurred, the cryoinjury caused complete loss of function in the limb. The return of motor act...

journal_title：British journal of anaesthesia

authors： Evans PJ,Lloyd JW,Green CJ

更新日期：1981-11-01 00:00:00

abstract：:Bilateral superior laryngeal nerve block was combined with topical application of local anaesthetic 140 times in 135 patients to anaesthetize the upper airway and facilitate tracheal intubation, laryngeal instrumentation, or to diminish the response to the endotracheal tube, in a patient already intubated. The techniq...

journal_title：British journal of anaesthesia

authors： Gotta AW,Sullivan CA

更新日期：1981-10-01 00:00:00

abstract：:To determine the influence of renal failure on the pharmacokinetics and neuromuscular blockade of Org NC 45 (Norcuron), a new monoquaternary homologue of pancuronium, 13 patients under halothane and nitrous oxide anesthesia were studied. Org NC 45 was administered by 2-min infusion in doses of 0.28 mg kg-1 (normal ren...

journal_title：British journal of anaesthesia

authors： Fahey MR,Morris RB,Miller RD,Nguyen TL,Upton RA

更新日期：1981-10-01 00:00:00

abstract：:Seventeen patients received morphine 0.2 mgkg-1 in a 10% dextrose solution i.m. (n = 5), extradurally (n = 6) and intrathecally (n = 6) for pain after operation. Morphine was measured in plasma by radioimmunoassay. Plasma immunoreactive morphine concentration was significantly less after intrathecal administration aft...

journal_title：British journal of anaesthesia

authors： Chauvin M,Samii K,Schermann JM,Sandouk P,Bourdon R,Viars P

更新日期：1981-09-01 00:00:00

abstract：:Five hundred and seventeen women in labour receiving extradural analgesia, using bupivacaine plain solution, were randomly allocated to one of three groups. Group A received 6-8ml of 0.5% solution, group B 10-14ml of 0.25% solution, and group C 6-8 ml of 0.25% solution. Spontaneous delivery occurred in 31.7% of patien...

journal_title：British journal of anaesthesia

authors： Thorburn J,Moir DD

更新日期：1981-09-01 00:00:00

abstract：:During resection of a Wilms' tumour in a 10-year-old girl, sudden bradycardia, hypotension and cyanosis developed, leading to cardiac arrest. It was thought that part of the tumour had caused a pulmonary embolus. After prompt resuscitation, cardiopulmonary bypass surgery was started within 20 min. At operation the lef...

journal_title：British journal of anaesthesia

authors： Akyön MG,Arslan G

更新日期：1981-08-01 00:00:00

abstract：:A double-blind trial was undertaken to compare the effects of trimeprazine tartrate (2 mg kg-1 or 4 mg kg-1) plus atropine 0.03 mg kg-1 for oral premedication of 192 children undergoing tonsillectomy. Demeanour before operation, side-effects after operation, recovery times and fluid balance were studied. Behaviour in ...

journal_title：British journal of anaesthesia

authors： Bramwell RG,Manford ML

更新日期：1981-08-01 00:00:00

abstract：:The possibility of an interaction between diazepam and pancuronium bromide was investigated in six patients undergoing general anaesthesia maintained with fentanyl, droperidol and nitrous oxide. Neuromuscular blockade was controlled using a feedback mechanism which automatically adjusted the rate of injection of pancu...

journal_title：British journal of anaesthesia

authors： Asbury AJ,Henderson PD,Brown BH,Turner DJ,Linkens DA

更新日期：1981-08-01 00:00:00

abstract：:The effects of some anaesthetics and other agents used in anaesthetic practice on the neuromuscular blocking activity of cumulative doses of Org NC 45 have been studied in cats anaesthetized with chloralose. As expected from studies with other neuromuscular blocking drugs, both inhalation and i.v. anaesthetics reduced...

journal_title：British journal of anaesthesia

authors： McIndewar IC,Marshall RJ

更新日期：1981-08-01 00:00:00

abstract：:Cumulation and interaction of neuromuscular blocking effects of neomycin and tubocurarine were determined on responses of the tibialis anterior muscle of the anaesthetized cat to indirect stimulation. Neuromuscular block produced by neomycin was cumulative despite rapid and apparent full recovery of twitch tension and...

journal_title：British journal of anaesthesia

authors： Durant NN,Lee C,Katz RL

更新日期：1981-06-01 00:00:00

abstract：:General anaesthesia for emergency surgery in a pressurized habitat is likely to involve the use of i.v. agents. The anaesthetic property of such agents is known to be antagonized by pressure, but the effect on their duration of action is not easily predicted. The recovery of mice from a single i.v. dose of Althesin, k...

journal_title：British journal of anaesthesia

authors： Shearer AJ,Ross JA,Manson HJ

更新日期：1981-05-01 00:00:00

abstract：:Relative humidity of air produced by simple compressors used to drive ventilators was measured at different working pressures. At normal working pressures, a relative humidity of 100% was found and condensation occurred, mainly at the high pressure air/oxygen mixer valve. This resulted in blockages and loss of accurac...

journal_title：British journal of anaesthesia

authors： Conely JI,Railton R,MacKenzie AI

更新日期：1981-05-01 00:00:00

abstract：:Gastric (GP) and lower oesophageal sphincter pressures (LOSP) were measured in non-pregnant female volunteers (group I) and pregnant women with (group III) or without (group II) heartburn. Patients in early pregnancy had greater gastric pressures than group I. Mean barrier pressure (LOSP-GP) was significantly decrease...

journal_title：British journal of anaesthesia

authors： Brock-Utne JG,Dow TG,Dimopoulos GE,Welman S,Downing JW,Moshal MG

更新日期：1981-04-01 00:00:00

abstract：:Profound postoperative respiratory depression after larger doses of fentanyl was partially reversed by 4-aminopyridine. This reversal was independent of FIO2' suggesting that the response was not dependent upon peripheral chemoreceptor-mediated drive. Similar reversal of fentanyl-induced depression by 4-aminopyridine ...

journal_title：British journal of anaesthesia

authors： Sia RL,Zandstra DF

更新日期：1981-04-01 00:00:00

abstract：:Cholinesterase phenotyping studies have been carried out in two laboratories on blood specimens from 28 patients shown to be susceptible to malignant hyperpyrexia. In contrast to previously published reports, no evidence could be found for an increase in the frequency of the E1u E1f genotype above that known to occur ...

journal_title：British journal of anaesthesia

authors： Evans RT,Iqbal J,Ellis FR,Halsall PJ,Dietz AA,Lubrano T,Rubinstein HM

更新日期：1981-03-01 00:00:00

abstract：:Intracuff pressure (c.p.) was measured continuously in 12 patients during prolonged periods of tracheal intubation. High residual volume--low pressure (floppy) and low residual volume--high pressure (conventional) cuffs were studied. The mean baseline c.p. at minimal occluding pressure was significantly smaller in flo...

journal_title：British journal of anaesthesia

authors： Jacobson L,Greenbaum R

更新日期：1981-01-01 00:00:00

abstract：:A study of core temperature monitoring during general anesthesia indicates that this can be introduced as a routine procedure in order to reduce mortality from malignant hyperpyrexia. The temperature profiles of 2410 patients are presented. Both mean rectal and mean oesophageal temperatures decreased during general an...

journal_title：British journal of anaesthesia

authors： Crocker BD,Okumura F,McCuaig DI,Denborough MA

更新日期：1980-12-01 00:00:00

abstract：:The effect of the administration of propranolol 0.15 mg per kg body weight i.v. on the metabolic response to pelvic surgery was compared with results in similar patients who had not received propranolol. The only significant difference between the two groups was a lower plasma insulin concentration in the beta-blockad...

journal_title：British journal of anaesthesia

authors： Cooper GM,Paterson JL,Mashiter K,Hall GM

更新日期：1980-12-01 00:00:00

abstract：:Blood concentrations of nitrous oxide were measured in anaesthetists, surgeons and theatre nurses. Comparison of anaesthetists and surgeons working in the same theatre showed that in ENT surgeons concentrations were greater (P < 0.01), while in general surgeons they were smaller (P < 0.003). Blood concentrations of ni...

journal_title：British journal of anaesthesia

authors： Krapez JR,Saloojee Y,Hinds CJ,Hackett GH,Cole PV

更新日期：1980-11-01 00:00:00

abstract：:Experiments were performed on rats using two analgesimetric tests (tail-flick; hot-plate) before and after injection i.v. of graded doses of aprotinin (12.5, 25.0 and 50 KIU g-1). A dose-related analgesic effect was noted with both tests. Prior administration of naloxone 0.001 mg g-1 i.p. inhibited the analgesic actio...

journal_title：British journal of anaesthesia

authors： Novelli GP,Pieraccioli E,Peduto VA,Festimanni F

更新日期：1980-11-01 00:00:00

abstract：:The calculation of pharmacokinetic parameters after a bolus injection of fentanyl allowed an i.v. infusion scheme which guarantees analgesia for the entire duration of surgery, with the advantage of steady plasma concentration and body content. In the initial phase after bolus injection, the serum concentration decrea...

journal_title：British journal of anaesthesia

authors： Hengstmann JH,Stoeckel H,Schüttler J

更新日期：1980-10-01 00:00:00

abstract：:The concentrations of volatile hydrocarbons were studied in breath samples from patients before and after anaesthesia. In patients to whom halothane was administered, there was a significant increase in the concentration of isobutene (from 0.43 +/- 0.09 to 4.66 +/- 2.22 nmol litre-1). There was no change in the concen...

journal_title：British journal of anaesthesia

authors： Hempel V,May R,Frank H,Remmer H,Köster U

更新日期：1980-10-01 00:00:00

abstract：:The anaesthetic and surgical problems associated with Caesarean section in eight grossly obese patients (weight 150-204 kg) are described. In addition to an increase in the frequency and severity of the complications of obesity, those weighing more than 150 kg present a panniculus which may weigh 70 kg. Extradural ana...

journal_title：British journal of anaesthesia

authors： Hodgkinson R,Husain FJ

更新日期：1980-09-01 00:00:00

abstract：:The activity of a new i.v. anesthetic agent ICI 35 868, a compound unrelated to currently used barbiturate, eugenol or steroid agents, has been examined in a range of animal species. Some of the properties of ICI 35 868 resemble those of thiopentone in that it is a rapidly acting agent which produces anaesthesia of sh...

journal_title：British journal of anaesthesia

authors： Glen JB

更新日期：1980-08-01 00:00:00

abstract：:This editorial looks at some of the various anesthesias used during pregnancy termination. Trichloroethylene, often a popular substitute for halothane, has been subjected to little evaluation. Only clinical study however, can actually establish the significance of myometrial depressant properties in the pregnant pat...

journal_title：British journal of anaesthesia

authors： Grant IS

更新日期：1980-08-01 00:00:00

abstract：:The 119 patients who had undergone previous Caesarean section lumbar extradural block was administered to 77 (65%); the other 42 (35%) received analgesia with ketobemidone 0.8-1.0 ml i.m. or nitrous oxide in oxygen intermittently, or both. Controlled i.v. infusion of oxytocin for induction or acceleration of labour wa...

journal_title：British journal of anaesthesia

authors： Carlsson C,Nybell-Lindahl G,Ingemarsson I

更新日期：1980-08-01 00:00:00

abstract：:Local reactions after i.v. injection of diazepam, flunitrazepam and isotonic saline were studied in patients who received extradural analgesia or general anaesthesia. The frequency of thrombophlebitis on the 1st, 3rd and 5th days after the injection of diazepam was 2.1%, 17.0% and 14.9% respectively, after flunitrazep...

journal_title：British journal of anaesthesia

authors： Mikkelsen H,Hoel TM,Bryne H,Krohn CD

更新日期：1980-08-01 00:00:00

abstract：:Amethocaine 1% solution was mixed with equal volumes of water, 0.9% saline or 10% dextrose to prepare respectively, hypobaric, isobaric and hyperbaric solutions which were compared for intradural spinal anaesthesia in 60 patients. Thirty patients received 10 mg and 30 patients received 15 mg of amethocaine. Injections...

journal_title：British journal of anaesthesia

authors： Brown DT,Wildsmith JA,Covino BG,Scott DB

更新日期：1980-06-01 00:00:00

abstract：:The cardiorespiratory effects of increasing respiratory frequency were investigated in two groups of dogs ventilated mechanically with a system which minimized apparatus and anatomical deadspace. In one group minute volume was constant whilst frequency was increased; in the second group minute volume was increased to ...

journal_title：British journal of anaesthesia

authors： Chakrabarti MK,Sykes MK

更新日期：1980-05-01 00:00:00

abstract：:The Myotest is a new nerve stimulator which can give train-of-four, single twitch (1 and 10 s) and tetanic stimuli. Power is supplied by standard batteries, which allow 200 h effective use. The impulse is unipolar constant current, and the amplitude can be adjusted between 0 and 40 mA. These factors, plus the electron...

journal_title：British journal of anaesthesia

authors： Viby-Mogensen J,Hansen PH,Jørgensen BC,Ording H,Kann T,Fries B

更新日期：1980-05-01 00:00:00

abstract：:Artery-to-muscle (A-M) onset time for five neuromuscular blocking agents was studied in 50 female patients under light endotracheal anaesthesia. Circulation to the right arm was occluded by a tourniquet and released 1 min after the injection i.v. into the left arm of a myoneural blocking drug. Muscle twitches were rec...

journal_title：British journal of anaesthesia

authors： Minsaas B,Stovner J

更新日期：1980-04-01 00:00:00

abstract：:Buprenorphine 0.3 mg or fentanyl 0.125 mg i.v. were used to supplement nitrous oxide anaesthesia in a double-blind investigation of 40 patients undergoing major abdominal surgery. Initially both narcotics appeared to suppress tachycardia and increased arterial pressure in response to surgery, but 80% of the patients w...

journal_title：British journal of anaesthesia

authors： Kay B

更新日期：1980-04-01 00:00:00